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Tratamiento de SLE. La dosis media inicial en adultos es mg. Prevención de ataques de la malaria agudos causados por P. Para niños, la dosis semanal es 6. Si las condiciones permiten, entonces la terapia preventiva se debería comenzar 2 semanas antes de entrar en la zona endémica. Si esto no es posible, entonces pueden dar a una inicial la dosis que carga dos veces: adultos - mg. Para adultos, deberían dar una dosis inicial de mg. Un método alternativo de tratamiento: la eficacia de una dosis sola de mg. Para niños, la dosis total de 32 mg.

El efecto tóxico en la retina es en gran parte dependiente de la dosis. El frecuencia de retinopathy con el uso de dosis hasta 6. Antes del principio de un curso largo del tratamiento con la medicina, un examen cuidadoso de ambos ojos se debería realizar. El examen debería incluir la definición de la agudeza visual, el examen del fundus, evaluación de visión en color y campos visuales. Durante la terapia, este examen se debería realizar al menos una vez cada 6 meses.

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Es aconsejable usar la precaución al administrar hydroxychloroquine a pacientes con hígado y enfermedad de riñón quien tendría que reducir la dosis de la medicina, y también debido a la posibilidad de la exposición de la medicina a la función de estos órganos en violaciones severas de la función del hígado o el riñón, la dosis se debería seleccionar bajo el control de concentraciones plasma de hydroxychloroquine.

Los niños son particularmente sensibles a los efectos tóxicos del 4-aminoquinolines, por tanto el cuidado se debería tomar para asegurar que hydroxychloroquine se almacene en sitios inaccesibles a niños. Plakvenil es ineficaz contra el chloroquine resistente las tensiones del Plasmodium falciparum, y también inactivo contra las formas de non-erythrocytic de Plasmodium vivax, Plasmodium malariae y Plasmodium ovale y por lo tanto no puede prevenir la infección por estos microorganismos cuando se prescribe para la prevención de ataques agudos de la malaria, y también no puede prevenir la enfermedad de la recaída causada por estos patógenos.